Preheat oven to 350°F (175°C). Don't skip preheating, it matters more than you think it does.
Prepare the panade: In a large bowl, whisk together eggs, milk, and ketchup. Add Panko breadcrumbs and let soak for 5 minutes. This step is magic. Seriously, don't rush it.
Add aromatics: Stir in chopped onion, garlic, parsley, Worcestershire sauce, salt, pepper, and Italian seasoning. Your kitchen should smell amazing right about now.
Incorporate meat: Add ground beef to the mixture. Using your hands or a fork, gently combine until just mixed. Do not overmix. This is where most people mess everything up.
Shape: Form mixture into a loaf shape on a parchment-lined baking sheet or place in a greased 9x5-inch loaf pan. Both work great but there's differences we'll talk about later.
Make glaze: Whisk together all glaze ingredients. Brush half over the meatloaf. Save the rest, you'll need it.
Bake: Cook for 45-60 minutes, applying remaining glaze every 15 minutes, until internal temperature reaches 160°F. Use a thermometer here. Guessing is for amateurs.
Rest: Let stand 10-15 minutes before slicing. I know it's hard to wait but this step separates good meatloaf from great meatloaf.